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Our editorial team selected the products on this list based on our own reviews, customer reviews and professional reviews weighted against each other. This data was used to determine a consensus to cover each different type of ergonomic mouse user. For each category, we carefully selected parameters based on our research and identified the products with the highest review score within those parameters.
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The practical reality of ergonomic design is that there's no single "best" ergonomic approach, because everyone's mousing needs and comfort needs are different. However, as an all-round approach to making your mousing more comfortable, Logitech's MX Ergo Wireless Trackball Mouse has a lot going for it.
Using a trackball in a fixed position rather than a mouse over an entire desk will constrain those movements that can lead to strain injuries. The actual trackball can sit in one of two positions, which gives it flexibility for multiple users or use cases. It also uses Logitech's extensive customisation software, so you can easily set up shortcuts for specific buttons.
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A lot of cheap mice claim to be ergonomic, but most of them are just plain old horizontal mice with just a little contouring on the sides. That's not an accusation you could point at the Mojo Perfect Grip Dual Mode Silent Vertical Mouse, which uses a grip style to limit movement and improve comfort.
It's a basic mouse in button terms, but online reviewers praise it not only for its lower cost, but also its smaller size if you've got shorter digits. It features Bluetooth for connectivity so if your laptop supports Bluetooth, you won't need a USB dongle or cable.
Some reviewers did note that despite the "silent" part of the name, the mouse buttons can be a little on the clicky side.
Logitech's G502 Lightspeed mouse is primarily pitched at the gaming crowd, but it's comfortable enough that anyone should consider it.
It's a horizontally oriented mouse with a side flange to rest your thumb on. The scroll wheel can quickly be switched between a smooth rolling style or a ratcheted style to suit different mobility needs. You can also dynamically change its DPI (dots per inch – effectively the rate at which it "reads" movement beneath its mousy body), so it's easy to set lots of scrolling for little distance if excess movement is an ergonomic concern.
It uses weights in the body to change its physical heft too, so you can modify it to meet your precise ergonomic needs. You can read more about the Logitech G502 Lightspeed in our full review.
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The Logitech MX Ergo Wireless Trackball Mouse is also our choice for the best trackball mouse. It scores highly with reviewers thanks to its support for both Bluetooth and 2.4Ghz connectivity via Logitech's included USB receiver.
Online users also generally praised the adjustable trackball angle, which can sit in two positions. Users also mention the fully rubberised base which means that it won't shift on your desk even if you're heavily scrolling or moving around.
It features adjustable DPI, so you can change how far a scroll movement goes to suit your individual needs, even if they change from adjusting an image with fine motions to more solid scrolling on, say, a web page. It also supports pairing to multiple devices – even across Windows 10 and macOS – if you do work across multiple PCs on a regular basis too.
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While it also exists in a wireless variant, the wired version of 3M's vertical ergonomic mouse is typically a little cheaper than its wire-free counterpart. You also naturally get the benefit of never running out of mouse power just because you forgot to change the batteries.
You still get the same basic design that 3M has offered over the long lifespan of this vertical mouse design, which focuses strongly on the ergonomics above all else. It comes in smaller and larger sizes too, so the common complaint of not fitting smaller or larger hands doesn't typically apply here.
Most online reviews noted the beneficial effects they felt once they'd gotten used to its unusual shape, although many noted that it's a very basic mouse in terms of buttons and configuration.
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Regular mouse users who are left-handed generally have to put up with "ambidextrous" options that are basically shapeless, but that's not quite the same story when it comes to ergonomic mice. There isn't a huge range of left-handed ergonomic mice, which is why the Evoluent Vertical Mouse is our pick for the best left-handed mouse.
The Evoluent Vertical Mouse – which also exists in a right-handed version – scores well with online reviewers for its range of buttons, comfortable grip and easily accessible scroll wheel. The speed at which the mouse moves the pointer is adjustable with a simple light on top to let you know the current setting.
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The trackball market isn't huge, but pretty much every trackball mouse can tack on the word "ergonomic" simply due to the way that they handle mouse movement duties.
Logitech's MX Ergo Wireless Trackball Mouse goes further than that, with an adjustable angle for the trackball itself. It only has two positions, but that's one more than any other trackball in this space. It's also helped by the inclusion of dual connectivity through both standard wireless with a USB receiver and Bluetooth connectivity, which means you could pair it to multiple devices without having to fuss about switching connectors or re-pairing every time you change.
Online reviewers also praised its adjustable DPI settings and robust feel, helped by the inclusion of a fully rubber base that means it stays put on your desk under most circumstances.
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3M's Wired Ergonomic Optical Mouse takes verticality to its logical endpoint, looking more like an old-school arcade joystick than anything else. The idea is sound, however, because it gives you the maximum possible amount of side wrist space to rest on.
It's available mostly as a wireless model and you can opt for different sizes which is important if you've got smaller or larger hands. Online reviews praised its attention to ergonomic detail and the level of comfort that they got from it, but all did note that there's quite the learning curve to get used to with a mouse of this style.
If you're still deciding which ergonomic mouse is best for you, compare the specs, features and prices of each option below.
We update our data regularly, but information can change between updates. Confirm details with the provider you're interested in before making a decision.
The single biggest challenge in comparing ergonomic mouse choices is that there's no single definition of what constitutes an "ergonomic" mouse. It's generally accepted that any mouse wanting to claim it is "ergonomic" should mean that it complies with ergonomic principles around comfort for use over a long period of time, but that's a very broad definition that also includes some specialised mice to help deal with particular mobility or comfort issues.
When buying an ergonomic mouse, consider the following factors:
Most proper ergonomic mice work on the principle of limiting unnecessary movement on comfort grounds, so having a cable in place isn't quite as much of an issue as it is with a standard mouse. That being said, a wireless ergonomic mouse is also easier to transport, and depending on connection method may not require sacrificing a USB port for connectivity, while every wired ergonomic mouse does.
Traditional mice have a horizontal shape, which means they sit flat to the ground. Ergonomic mice, on the other hand, also come in vertical designs that involve resting the side of your hand rather than the flat of your palm on the mouse itself. Research is mixed, with some studies suggesting that they may aid in reducing fatigue, while others suggest that vertically oriented mice are not specifically better for everyone.
Many users find trackball-based mice, where a rolling ball on the side or top of the mouse is used to move onscreen elements around, more comfortable for longer working periods. However, they're typically not as good for more precise work as a full optical sensor due to lower read rates on the ball itself, and they're generally seen as poor for most gaming uses.
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